Success and Anticipated Pregnancy Outcomes From Oocyte Cryopreservation



In 2005, a study was published, which compared and examined the success rates for frozen and unfrozen oocytes. Parameters under study included live birth rates, clinical pregnancy, and implantation rates. In vitro fertilization success rates with slow-frozen oocytes were found to be significantly lower when compared with in-vitro fertilization success rates for oocytes that had not been frozen. The researchers felt that further studies needed to be conducted in order to determine the efficiency and safety of this technique.

In May 2013, researchers from New York Medical College and the University of California at Davis have tabulated age-specific probabilities of live births occurring after in-vitro fertilization (IVF) using frozen eggs. This study was a meta-analysis of oocyte cryopreservation cycles utilizing patient data, which reported the probability of live birth resulting from IVF cycles.

Although in-vitro fertilization has been utilized extensively in cases of infertility, egg freezing is a relatively recent technique. This elective procedure enables women to preserve their fertility, enabling them to have future opportunities for bearing children. Until now, women who had undergone oocyte cryopreservation were unable to predict their chances of a live birth once the embryos were transferred. By collecting and using raw data from ten previously published studies on oocyte cryopreservation, the researchers were able to amass the world’s largest database on the outcomes of pregnancy after this procedure.

The database included data from 2,265 egg freezing cycles in 1,805 women in Europe and the U.S. The amount of data was sufficient enough to allow the researchers to generate and extrapolate numerical values to be used to determine egg freezing success rates based on such factors as a patient’s age, number of oocytes frozen, and the method of egg freezing used, whether it be slow freezing or vitrification.

This study allows for the utility of a live pregnancy rate estimator that can be used to calculate and predict individual chances for live birth. Using the estimates provided, women can make a well-informed decision about undergoing the elective egg freezing procedure independently or in addition to an IVF cycle.

As expected, the study underscored that egg freezing success rates decline with age. However, the drop in success rates continues more sharply for women older than 36 years of age. Pregnancies can, however, result from the transfer and implantation of previously frozen eggs in patients as old as 44 years of age, but the success rates are less optimistic after age 42.

Date: Posted on by Victory A.R.T. Laboratory Phils, Inc.
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About Victory A.R.T. Laboratory Phils, Inc.

Victory A.R.T. Laboratory Phils Inc. is part of the Hong Kong based Victory Group of A.R.T. Laboratories and is the pioneer IVF laboratory here in the Philippines and have done the most number of successful IVFs in the country, up to 300 cases yearly under the leadership of its Medical Director, .